Mesenteric and renal vascular effects of diadenosine polyphosphates (APnA)
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چکیده
منابع مشابه
Mesenteric and renal vascular effects of diadenosine polyphosphates (APnA).
Diadenosine polyphosphates (APnA) are endogenous dinucleoside molecules consisting of two adenosine moieties linked via their 5'-ribose positions by a variable number of phosphate groups. APnA have been shown to be present in different cell types and to be released from platelets as well as co-released with catecholamines and ATP from bovine adrenal medulla. Candidate metabolites of APnA are AT...
متن کاملVasoactivity of diadenosine polyphosphates in human small renal resistance arteries.
BACKGROUND We examined for the first time the vascular effects of purinergic agents that contribute to the regulation of peripheral vascular resistance in human small renal resistance arteries (hRRAs). METHODS AND RESULTS Diadenosine polyphosphates (ApnAs, n = 3-6) and ATP, mounted in a microvessel myograph, caused vasoconstriction in hRRAs (rank order of potency: Ap5A > Ap6A = Ap4A > Ap3A = ...
متن کاملThe effects of diadenosine polyphosphates on the cardiovascular system.
Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous, naturally occurring molecules. They form a recently identified class of compounds derived from ATP and consist of two adenosine molecules bridged by up to six phosphate groups. These compounds are stored in high concentrations in platelet dense granules and are released when platelets become ac...
متن کاملEffects of Diadenosine Polyphosphates on Vasoconstriction and Cytosolic Calcium in Vascular Smooth Muscle and Glomerular Mesangial Cells
The effects of diadenosine tetraphosphate (AP4A), diadenosine pentaphosphate (AP5A), and diadenosine hexaphosphate (AP6A) on the force of renal resistance vessels and aortic strips were measured using a small vessel myograph. Spectrofluorophotometric measurements of cytosolic free calcium concentrations ([Ca2+]i) in cultured rat vascular smooth muscle cells (VSMC) and glomerular mesangial cells...
متن کاملDual roles of diadenosine polyphosphates in corneal epithelial cell migration.
PURPOSE To investigate the influence of diadenosine polyphosphates on the rate of corneal epithelial cell migration. METHODS Primary corneal epithelial cell cultures were obtained from New Zealand White rabbits. Immunocytochemical experiments were performed by fixing the cells with 4% paraformaldehyde (PFA) and incubated with cytokeratin 3 primary antibody, which was subsequently incubated wi...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2002
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(02)00533-3